Effect of Exogenous Surfactant (Calfactant) in Pediatric Acute Lung Injury<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>
نویسندگان
چکیده
منابع مشابه
Effect of exogenous surfactant (calfactant) in pediatric acute lung injury: a randomized controlled trial.
CONTEXT Despite evidence that patients with acute lung injury (ALI) have pulmonary surfactant dysfunction, trials of several surfactant preparations to treat adults with ALI have not been successful. Preliminary studies in children with ALI have shown that instillation of a natural lung surfactant (calfactant) containing high levels of surfactant-specific protein B may be beneficial. OBJECTIV...
متن کاملCARING FOR THE CRITICALLY ILL PATIENT Effect of Exogenous Surfactant (Calfactant) in Pediatric Acute Lung Injury A Randomized Controlled Trial
ACUTE RESPIRATORY DISTRESS syndrome (ARDS) was originally termed the adult respiratory distress syndrome because it resembled the clinical picture of infant respiratory distress syndrome (IRDS), and both exhibited hyaline membranes at autopsy. Avery and Mead first reported that lung surfactant quantity and activity were abnormal in infants with IRDS and surfactant replacement has subsequently b...
متن کاملComputed tomography assessment of exogenous surfactant-induced lung reaeration in patients with acute lung injury
INTRODUCTION Previous randomized trials failed to demonstrate a decrease in mortality of patients with acute lung injury treated by exogenous surfactant. The aim of this prospective randomized study was to evaluate the effects of exogenous porcine-derived surfactant on pulmonary reaeration and lung tissue in patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS). M...
متن کاملCuban Exogenous Pulmonary Surfactant in Treatment of Pediatric Acute Respiratory Distress Syndrome
INTRODUCTION Acute respiratory distress syndrome is a complex heterogeneous disorder with low incidence but high case fatality in children. Treatment with pulmonary surfactants is a possible option. Surfacen, a Cuban exogenous pulmonary surfactant, has been proven safe and effective in premature newborns with hyaline membrane disease, but evidence regarding its effi cacy in older children is st...
متن کاملCost-effectiveness of exogenous surfactant therapy in pediatric patients with acute hypoxemic respiratory failure.
OBJECTIVE To determine whether the use of exogenous surfactant (Infasurf) in pediatric acute hypoxemic respiratory failure is cost-effective. DESIGN Deterministic cost-effectiveness analysis based on a Markov model. The model was calibrated using outcomes and resource utilization observed in a multiple-centered, prospective, randomized, controlled unblinded trial of Infasurf in pediatric acut...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: JAMA
سال: 2005
ISSN: 0098-7484
DOI: 10.1001/jama.293.4.470